AN IMPROVED AND RELIABLE METHOD FOR THE INDUCTION OF COLITIS IN RATS USING 2,4,6-TRINITROBENZENE SULFONIC ACID

We performed this study to develop a reliable method for inducing colitis in rats using 2,4,6-trinitrobenzene sulfonic acid (TNBS) to reduce the variation in ulcer size.A pair of ring Electric Knife Sharpener Parts forceps was used to clamp the colon and 0.1 M TNBS in ethanol was injected into the luminal side of the clamped portion.This method res